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Inhibitory potentials of curcumin analogues to cytochrome p450 isoenzymes activity, quantitative structures activity relationships (qsars) and docking simulations to the cyp 2d6 homology model

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: ANDARINI, Mayagustina (The National Agency for Drug and Food Control, the Republic of Indonesia, Jakarta Pusat, Indonesia)
  • Co-author(s): Stjernschantz, Eva (Division of Molecular Toxicology, Vrije Universiteit Amsterdam, AMSTERDAM, Netherlands)
    Appiah-Opong, Regina (Division of Molecular Toxicology, Vrije Universiteit Amsterdam, AMSTERDAM, Netherlands)
    De Graaf, Chris (Division of Medicinal Chemistry, Vrije Universiteit Amsterdam, AMSTERDAM, Netherlands)
    Oostenbrink, Chris (Division of Molecular Toxicology, Vrije Universiteit Amsterdam, AMSTERDAM, Netherlands)
    Commandeur, Jan (Division of Molecular Toxicology, Vrije Universiteit Amsterdam, AMSTERDAM, Netherlands)
    De Esch, Iwan (Division of Medicinal Chemistry, Vrije Universiteit Amsterdam, AMSTERDAM, Netherlands)
    Vermeulen, Nico (Division of Molecular Toxicology, Vrije Universiteit Amsterdam, AMSTERDAM, Netherlands)
  • Abstract:



    Curcumin is one of biologically active β-diketone constituents of turmeric (Curcuma longa, L). Diferuloylmethane is responsible for the yellow colour, and consists of curcumin (94%), demethoxycurcumin (6%) and bisdemethoxycurcumin (0.3%). The numerous biological effects demonstrated by curcumin indicate that turmeric in the diet can be..

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Last update 4 October 2019

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