Menu
  • Join
  • Login
  • Contact
 

Search abstracts


Characterization of inhibitory effects of losartan on paclitaxel metabolism using recombinant cytochrome p450s

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: TODA, Takaki (Hokkaido Pharmaceutical University, Otaru, Japan)
  • Co-author(s): Inotsume, Nobuo (Hokkaido Pharmaceutical University, OTARU, Japan)
    Mukai, Yuji (Hokkaido Pharmaceutical University, OTARU, Japan)
    Kudo, Seiichiro (Hokkaido Pharmaceutical University, OTARU, Japan)
    Yamawaki, Mitsuyoshi (Hokkaido Pharmaceutical University, OTARU, Japan)
    Mori, Akinori (Hokkaido Pharmaceutical University, OTARU, Japan)
    Hayakawa, Toru (Hokkaido Pharmaceutical University, OTARU, Japan)
    Eliasson, Erik (Karolinska Institute, STOCKHOLM, Sweden)
    Ask, Birgitta (Karolinska Institute, STOCKHOLM, Sweden)
    Rane, Anders (Karolinska Institute, STOCKHOLM, Sweden)
  • Abstract:

    Objective: We have already found that losartan inhibits metabolism of arachidonic acid. Arachidonic acid is mainly metabolized by CYP2C8, 2C9, and 2J2 while paclitaxel by 2C8 and 3A4, in human liver microsomes. In this study, we have performed to investigate the inhibitory effect of losartan on paclitaxel metabolism using recombinant 2C8..

  • The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 4 October 2019

FIP Congresses