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Effects of oridonin on hepatic cytochrome p450 expression and activities in pxr-humanized mice

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: ZHANG, Yiwen (Zhejiang Cancer Hospital)
  • Co-author(s): Yiwen Zhang: Laboratory of Clinical Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China
    Mei-Hua Bao: Department of Anatomy, Histology and Embryology, Changsha Medical University, Changsha, China
    Like Zhong: Laboratory of Clinical Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China
    Ping Huang: Laboratory of Clinical Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China
  • Abstract:

    Background

    Oridonin, the major terpene found in Rabdosia rubescens, is widely used as dietary supplement or therapeutic drug, while the effects of oridonin on CYP450 were still unclear [1]. The pregnane X receptor (PXR) is an important regulatory factor for major drug metabolism enzyme cytochrome P450 (CYPs), and it has been reported to..

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Last update 13 May 2019

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