Molecular modeling and synthesis of some new 2-substituted benzimidazoles inhibiting vegfr-2 & c-met

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: IBRAHIM, Hebatalla (Future university in Egypt, Pharmaceutical chemistry)
  • Co-author(s): Hebatalla ahmed Ibrahim
    Hanan Refaat: Pharmaceutical chemistry, Future university in Egypt, Cairo, Egypt
  • Abstract:

    Background

    Targeting multiple biochemical pathways of cancer can be achieved by a single chemical entity that could modulate several targets of a multifactorial disease. VEGFR-2 and c-Met kinases collaborate synergistically in promoting angiogenesis and progression of various human cancers.[1]

     

    Methods

    Preliminary molecular docking and

    ..

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