A prospective, randomized study comparing standard dosing and genotype dosing of warfarin therapy

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: LEE, Kyungeun (Chungbuk National University, College of Pharmacy, Cheongju-si, Korea, Republic Of)
  • Co-author(s): Kyung Eun Lee: College of Pharmacy, Chungbuk National University, Cheongju-si, Korea, Republic Of
    Gwan Yung Lee: College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea, Republic Of
    Jee Eun Chung: College of Pharmacy, Sungkyunkwan University, Suwon-si, Korea, Republic Of
    Jeong Yee: College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea, Republic Of
    Hyun Jeong Kim: College of Pharmacy, Chungbuk National University, Cheongju-si, Korea, Republic Of
    Joo Hee Kim: College of Pharmacy, Ajou University, Suwon, Korea, Republic Of
    Hye Sun Gwak: College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea, Republic Of
    Byung Chul Chang: Department of Thoracic & Cardiovascular Surgery, Yonsei University Medical Center, Seoul, Korea, Republic Of
  • Abstract:

    Methods

    We conducted a randomized, controlled trial involving patients with heart valve replacements. The primary endpoint was the percentage of out-of-range INRs in each group over the period of hospitalization and the first hospital revisit (a week after discharge). Genotyping of CYP2C9 (rs1057910), VKORC1 (rs9934438), and CYP4F2 (rs2108622) was..

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