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Modeling and prediction of the effect of transporters on differences of unbound drug concentrations between the plasma, brain and cerebrospinal fluid

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: SUGIYAMA, Yuichi (RIKEN Innovation center, Sugiyama laboratory, Yokohama, Japan)
  • Co-author(s): Yuichi Sugiyama: Sugiyama laboratory, RIKEN Innovation center, Yokohama, Japan
  • Abstract:

    Because of the difficulty in measuring directly the unbound drug concentration in the brain
    (Cu, brain) in humans, the concentration in the cerebrospinal fluid (CSF) (CCSF) has been used as a surrogate for Cu, brain. However, the factors responsible for a difference in the unbound concentration in the brain and CSF remain obscure. A

    ..

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Last update 4 October 2019

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