Modeling and prediction of the effect of transporters on differences of unbound drug concentrations between the plasma, brain and cerebrospinal fluid
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Presentation
- By: SUGIYAMA, Yuichi (RIKEN Innovation center, Sugiyama laboratory, Yokohama, Japan)
- Co-author(s): Yuichi Sugiyama: Sugiyama laboratory, RIKEN Innovation center, Yokohama, Japan
Because of the difficulty in measuring directly the unbound drug concentration in the brain..
(Cu, brain) in humans, the concentration in the cerebrospinal fluid (CSF) (CCSF) has been used as a surrogate for Cu, brain. However, the factors responsible for a difference in the unbound concentration in the brain and CSF remain obscure. A The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.