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Therapeutic efficacy and safety of long-term stored hemoglobin-vesicles in a rat model of hemorrhagic shock

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TOKUNO, Masahiro (Sojo University, Kumamoto, Japan)
  • Co-author(s): Masahiro Tokuno: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Kazuaki Taguchi: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Keishi Yamasaki: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan;DDS Research Institute, Sojo University, Kumamoto, Japan
    Hiromi Sakai: Department of Chemistry, Nara Medical University, Nara, Japan
    Masaki Otagiri: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan;DDS Research Institute, Sojo University, Kumamoto, Japan
  • Abstract:

    Backgrounds

    Hemoglobin-vesicles (HbV) have been developed as red blood cell (RBC) substitutes. In vitro experiments showed that HbV suspensions are structurally and physicochemically stabile for a year, which indicate that HbV can be stored for more than 1 year. However, it remains unclear that long-term stored HbV administration could effectively..

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Last update 4 October 2019

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