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The impact of ethanol content and neutralizer selection on the rheology and stability of hydroalcoholic carbomer gels for topical drug delivery

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TAN, Bernice Mei Jin (ANGUS Chemical Company, ANGUS Life Sciences, Singapore, Singapore)
  • Co-author(s): Bernice Mei Jin Tan: ANGUS Life Sciences, ANGUS Chemical Company, Singapore, Singapore
  • Abstract:

    Backgrounds

    Carbomers are cross-linked polyacrylic acid polymers used as gelling agents in topical drug products. Gel formation occurs in two stages: (i) dispersion and hydration and (ii) neutralization of -COOH groups by a basic compound. In order to solubilize lipophilic drugs, non-polar solvents like ethanol are added to gels. The compatibility

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Last update 4 October 2019

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