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Collapse Temperature Modifiers in Freeze-Dried Protein Formulations

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HAEUSER, Christina (F. Hoffmann-La Roche / University of Basel, Late Stage Pharmaceutical Processing Development / Pharmaceutical Sciences, Basel, Switzerland)
  • Co-author(s): Christina Haeuser: Late Stage Pharmaceutical and Processing Development, Pharmaceutical Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland;Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland
    Pierre Goldbach: Late Stage Pharmaceutical and Processing Development, Pharmaceutical Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland
    Joerg Huwyler: Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland
    Andrea Allmendinger: Late Stage Pharmaceutical and Processing Development, Pharmaceutical Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland
  • Abstract:

    Backgrounds

    Freeze-drying of biopharmaceuticals is a lengthy and therefore expensive process step used to improve product stability. Hence process optimization mainly focuses on reducing cycle time which can be achieved by e.g. increasing primary drying temperature. However, product temperatures above the glass transition temperature (T’g), which..

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Last update 4 October 2019

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