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Dynamics of ibuprofen in amorphous solid dispersions

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: FERRAND-DRAKE, Gustav (Göteborg, Sweden)
  • Co-author(s): Gustav Ferrand-Drake: Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
    Anette Larsson: Applied Chemistry, Chalmers University of Technology, Gothenburg, Sweden
    Joel Wanemark: Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
    Josef Rizell: Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
    Anna Viridén: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Hanna Matic: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Anders Borde: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Johan Breitholz: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Susanna Abrahamsén-Alami: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Aleksandar Matic: Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
  • Abstract:

    Backgrounds

    Amorphous Solid Dispersions (ASD) raises solubility of pharmaceuticals compared to crystalline counterparts. Development of ASDs with sufficient stability against crystallization combined with enhanced release performance is crucial for commercial viability. What determines stability is disputed, but molecular mobility and relaxational
    ..

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Last update 4 October 2019

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