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Novel liposomal formulations of S-propargyl-cysteine for sustained-release of hydrogen sulfide for heart failure

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: MAO, Yicheng (Fudan University, School of Pharmacy, Shanghai, China)
  • Co-author(s): Yicheng Mao: School of Pharmacy, Fudan University, Shanghai, China
    Ba Hieu Tran: School of Pharmacy, Fudan University, Shanghai, China
    Lingling Chang: School of Pharmacy, Fudan University, Shanghai, China
    Bo Tan: Department of Clinical Pharmacology, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Wanwan Jia: School of Pharmacy, Fudan University, Shanghai, China
    Tao Dai: School of Pharmacy, Fudan University, Shanghai, China
    Wei-Ping Zhang: Department of Hematology, Institute of Hematology of PLA, Changhai Hospital, Shanghai, China
    Yi Zhun Zhu: School of Pharmacy, Macau University of Science and Technology, Macau, Macao
  • Abstract:

    Backgrounds

    S-propargyl-cysteine (SPRC) is an endogenous modulator of H2S. It has proved strong cardioprotective, anti-inflammtory and tumor suppressive effects.

    Aims

    To produce stable and sustainable H2S, we developed liposomal SPRC and studied the cardioprotective effects on HF rats.

    Methods

    The charged lipids sterylamine (SA) and dicetylphosphate

    ..

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Last update 4 October 2019

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