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Pharmacokinetic evaluation of doxorubicin containing lipiodol-based emulsion and drug-eluting beads used in the treatment of intermediate hepatocellular carcinoma

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: DUBBELBOER, Ilse (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
  • Co-author(s): Ilse R. Dubbelboer: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Elsa Lilienberg: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Amar Karalli: Department of Radiology, Karolinska University Hospital in Huddinge, Stockholm, Sweden;Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
    Rimma Axelsson: Department of Radiology, Karolinska University Hospital in Huddinge, Stockholm, Sweden;Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
    Torkel B. Brismar: Department of Radiology, Karolinska University Hospital in Huddinge, Stockholm, Sweden;Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
    Charlotte Ebeling Barbier: Department of Radiology, Uppsala University Hospital, Uppsala, Sweden
    Agneta Norén: Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Frans Duraj: Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Ulf Bondesson: Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute (SVA), Uppsala, Sweden
    Mikael Hedeland: Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute (SVA), Uppsala, Sweden
    Erik Sjögren: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Per Stål: Unit of Gastroenterology, Department of Internal Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden;Department of Digestive Diseases, Karolinska University Hospital in Huddinge, Stockholm, Sweden
    Rickard Nyman: Department of Radiology, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
    Hans Lennernäs: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    Doxorubicin containing lipidodol-based emulsions (LIPDOX) and drug-eluting beads (DEBDOX) are used in the treatment of hepatocellular carcinoma. Although profoundly different from a pharmaceutical perspective, both drug delivery systems are equally effective at treating the illness.

    Aims

    The aim of this study was to compare the in vivo

    ..

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Last update 4 October 2019

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