Menu
  • Join
  • Login
  • Contact
 

Search abstracts


iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening studies

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BRODIN, Birger (University of Copenhagen, Department of Pharmacy, Copenhagen, Denmark)
  • Co-author(s): Burak Ozgür: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
    Lasse Saaby: Bioneer-Pharma, University of Copenhagen, Copenhagen,
    Birger Brodin: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  • Abstract:

    Backgrounds

    The efflux transporter P-glycoprotein (P-gp, product of the MDR1/ABCB1 gene) hinders uptake of drug compounds to the brain, limits intestinal uptake, is a cause of resistance to chemoterapeutics and a potential "site" for drug-drug interaction . Regulatory agencies therefore recommend that new API's are evaluated with respect to P-gp..

  • The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 4 October 2019

FIP Congresses