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Use of a Time-Resolved Fluorescence Resonance Energy Transfer-based screen to identify a novel claudin-4 binding compound that attenuates the tight junction barrier

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: WATARI, Akihiro (Osaka University, Graduate School of Pharmaceutical Sciences, Suita, Japan)
  • Co-author(s): Akihiro Watari: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Kiyohito Yagi: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Masuo Kondoh: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
  • Abstract:

    Backgrounds

    Claudins, a 27-member family of proteins, play a pivotal role in maintaining tight junction (TJ) seals in epithelial tissue. The C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) binds to claudin-4, which is a main component of the TJ in mucosal epithelial cells, and reversibly modulates TJ seals, yielding an..

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Last update 4 October 2019

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