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The effect of sparkling water on intraluminal formulation behaviour and systemic drug performance in man

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: VAN DEN ABEELE, Jens (KU Leuven, Drug Delivery and Disposition, Leuven, Belgium)
  • Co-author(s): Jens Van Den Abeele: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
    Joachim Brouwers: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
    Jan Tack: Department of Gastroenterology, UZ Leuven, Leuven, Belgium
    Patrick Augustijns: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
  • Abstract:

    Backgrounds

    In the fasted stomach, periods of contractile quiescence alternate periods of intense contractile activity. In daily practice, gastric contractile activity during drug intake is not known, possibly leading to marked intra- and inter-individual variability in dosage form disintegration, gastric drug emptying and subsequent systemic drug

    ..

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Last update 4 October 2019

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