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Interactions of tea catechins with renal organic anion transporters

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: NABEKURA, Tomohiro (Aichi Gakuin University, School of Pharmacy, Nagoya, Japan)
  • Co-author(s): Tomohiro Nabekura: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    Tatsuya Kawsaki: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    Yuichi Uwai: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
  • Abstract:

    Backgrounds

         Organic anion transporter 1 (OAT1, SLC22A6) and 3 (OAT3, SLC22A8) are expressed in the basolateral membrane of renal proximal tubular cells.  OAT1 and OAT3 mediate tubular secretion of clinically important drugs, including antibiotics, antivirals, and diuretics.  Therefore, OAT1 and OAT3 play key roles in renal elimination of drugs.

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Last update 4 October 2019

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