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A multiparticulate delayed-release platform for oral delivery of a novel ghrelin agonist peptide to rodents: formulation design and in vitro characterization.

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HOWICK, Ken (University College Cork, Pharmacy, Cork, Ireland)
  • Co-author(s): Ken Howick: School of Pharmacy, University College Cork, Cork, Ireland;Anatomy & Neuroscience, University College Cork, Cork, Ireland;Food for Health Ireland, University College Cork, Cork, Ireland
    Harriët Schellekens: Anatomy & Neuroscience, University College Cork, Cork, Ireland;APC Microbiome Institute, University College Cork, Cork, Ireland;Food for Health Ireland, University College Cork, Cork, Ireland
    John F Cryan: Anatomy & Neuroscience, University College Cork, Cork, Ireland;APC Microbiome Institute, University College Cork, Cork, Ireland
    Brendan T Griffin: School of Pharmacy, University College Cork, Cork, Ireland;Food for Health Ireland, University College Cork, Cork, Ireland
  • Abstract:

    Backgrounds

    Ghrelin is an orexigenic peptide which has received considerable focus in treating appetite disorders. Dysregulation of the ghrelin axis is a factor in age- and disease-related cachexia. We have identified dairy-derived peptide hydrolysates with ghrelin receptor (GHSR-1a) agonist activity.

    Aims

    To design an oral delivery platform to

    ..

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Last update 4 October 2019

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