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In vitro and in silico analysis of uptake of sialyl LewisX mimic-decorated liposomes in inflamed endothelial cells

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HASHIDA, Mitsuru (Kyoto University, Graduate School of Pharmaceutical Sciences, Kyoto, Japan)
  • Co-author(s): Mitsuru Hashida: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Chanikarn Chantarasrivong: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Akiharu Ueki: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan
    Shinya Nakamura: Faculty of Pharmacy, Kindai University, Osaka, Japan
    Isao Nakanishi: Faculty of Pharmacy, Kindai University, Osaka, Japan
    Yuriko Higuchi: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Hiromune Ando: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan
    Fumiyoshi Yamashita: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Makoto Kiso: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan
  • Abstract:

    Backgrounds

    Sialyl LewisX (sLeX) is a natural ligand of E-selectin overexpressed in inflamed endothelium. sLeX is a potential targeting ligand for E-selectin-mediated drug delivery, but the synthesis of sLeX is complicated.

    Aims

    The aims of this study are (1) to develop liposomes bearing structurally simplified novel sLeX analogs, (2) to characterize

    ..

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Last update 4 October 2019

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