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Apparent solubility of drugs in Simulated Achlorhydric Gastric Fluid and Fasted State Simulated Intestinal Fluid with low respectively high bile concentration.

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: FAGERBERG, Jonas (University of Bath, Department of Pharmacy and Pharmacology, Bath, United Kingdom)
  • Co-author(s): Jonas Henrik Fagerberg: Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
    Hasnaa Jabbar: Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
    Panagiota Zarmpi: Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
    Nikoletta Fotaki: Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  • Abstract:

    Backgrounds

    Gastric achlorhydria and variation in bile excretion have been shown to affect the absorption of oral drugs.

    Aims

    To better understand these factors we have developed 3 biorelevant dissolution media reflecting achlorhydric gastric conditions and fasted intestinal conditions with low and high bile contents. The media was used to measure

    ..

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Last update 4 October 2019

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