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Physiologically-based approach to predict dopamine D2 receptor occupancy of antipsychotics in brain: translation from rat to human

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: WONG, Yin Cheong (Leiden University, Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands)
  • Co-author(s): Yin Cheong Wong: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden Univeristy, Leiden, Netherlands
    Maddalena Centanni: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden Univeristy, Leiden, Netherlands

    Elizabeth de Lange: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands
  • Abstract:

    Backgrounds

    Receptor occupancy (RO) is a translational biomarker for assessing drug efficacy, which could facilitate both dose optimization of existing drugs and evaluation of drug candidates.

     

    Aims

    We aimed to apply a physiologically-based pharmacokinetic (PBPK) modeling approach to predict the dopamine D2 RO of antipsychotics. 

     

    Methods

    Risperidone

    ..

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Last update 4 October 2019

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