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Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine
against pancreatic cancer

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HONG, Soon Sun (Inha University School of Medicine, Biomedical Sciences, Incheon, Korea, Republic Of)
  • Co-author(s): Soon Sun Hong: Department of Biomedical Sciences, Inha University School of Medicine, Incheon, Korea, Republic Of
    Kyung Hee Jung: Department of Biomedical Sciences, Inha University School of Medicine, Incheon, Korea, Republic Of
    Joo Han Lim: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea, Republic Of
    Chae-Ok Yun: Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea, Republic Of
    You-Sun Kim: Department of Biochemisty, College of Medicine, Ajou University, Korea, Republic Of
  • Abstract:

    Backgrounds

    Pancreatic cancer exhibits a pronounced collagen-rich stromal reaction, which induces chemoresistance by inhibiting drug diffusion into the tumor.

    Aims

    To examine the ability of combined treatment with gemcitabine and an oncolytic adenovirus expressing relaxin(YDC002), which degrades extracellular matrix, to efficiently treat

    ..

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Last update 4 October 2019

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