RNAi accessory factor TAR-RNA binding protein is involved in anti-viral innate immunity against Picornavirus infection
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: KOMURO, Akihiko (Niigata University of Pharmacy and Applied Life Sciences, Biochemistry, Niigata, Japan)
- Co-author(s): Akihiko Komuro: Department of Biochemistry, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Curt Horvath: Department of Molecular Biosciences, Northwestern University, Evanston, United States
Picornavirus cause clinical symptoms such as aseptic meningitis, encephalitis, myocarditis, and hepatitis etc. RNA helicase proteins, RIG-I, MDA5 and LGP2 detect viral RNAs in infected cells. Sensing of viral RNAs by these sensors rapidly initiate anti-viral responses. LGP2 and MDA5 cooperatively detect Picornavirus RNAs, although.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.