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RNAi accessory factor TAR-RNA binding protein is involved in anti-viral innate immunity against Picornavirus infection

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: KOMURO, Akihiko (Niigata University of Pharmacy and Applied Life Sciences, Biochemistry, Niigata, Japan)
  • Co-author(s): Akihiko Komuro: Department of Biochemistry, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Curt Horvath: Department of Molecular Biosciences, Northwestern University, Evanston, United States
  • Abstract:

    Backgrounds

    Picornavirus cause clinical symptoms such as aseptic meningitis, encephalitis, myocarditis, and hepatitis etc. RNA helicase proteins, RIG-I, MDA5 and LGP2 detect viral RNAs in infected cells. Sensing of viral RNAs by these sensors rapidly initiate anti-viral responses. LGP2 and MDA5 cooperatively detect Picornavirus RNAs, although

    ..

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Last update 4 October 2019

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