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Functional characterization of 21 allelic variants of dihydropyrimidinase

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HIRATSUKA, Masahiro (Tohoku University, Graduate School of Pharmaceutical Sciences, Sendai, Japan)
  • Co-author(s): Eiji Hishinuma: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Fumika Akai: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Masamitsu Maekawa: Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan
    Nariyasu Mano: Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan
    Noriyasu Hirasawa: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Masahiro Hiratsuka: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan;Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan;Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
  • Abstract:

    Backgrounds

    Dihydropyrimidinase (DHP), encoded by DPYS gene, is the second enzyme in the catabolic pathway of uracil and fluoropyrimidine drugs such as 5-fluorouracil. DHP catalyzes the hydrolysis of dihydrouracil and fluorodihydrouracil. Deficiency or low activity of DHP could cause severe adverse reactions during fluoropyrimidine therapy. Several ..

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Last update 4 October 2019

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