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Impact of Drug Distribution within the Liver on Measurement of Metabolic Elimination Rate Constants (k) and Clearance (CL)

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: SODHI, Jasleen (University of California San Francisco, Bioengineering and Therapeutic Sciences, San Francisco, United States)
  • Co-author(s): Jasleen Sodhi: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
    Leslie Benet: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
  • Abstract:

    Backgrounds

    Drug discovery requires accurate prediction of human hepatic CL. However, universally accepted methods of in vitro-to-in vivo extrapolation (IVIVE) underpredict in vivo values by ~9 fold, and vary by drug. Models consider the liver as homogenous, rather than a heterologous environment composed of both aqueous and lipophilic regions into ..

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Last update 4 October 2019

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