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Discovery of a BD1 selective inhibitor of BRD4 and co-targeting its interaction with AMPK-modulating autophagic cell death in breast cancer
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: LIU, Bo (Chengdu, China)
- Co-author(s): Leilei Fu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center for Biotherapy, Sichuan university, Chengdu, China
Bo Liu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center for Biotherapy, Sichuan university, Chengdu, China
BackgroundsBRD4 is an attractive cancer target, yet its protein-protein interactions (PPIs), which is relevant to therapeutic effects of BRD4 inhibitors, are not well understood. Induction of autophagic cell death (ACD) has been emerging as a new strategy; therefore, targeting ACD for discovering a BRD4 inhibitor will be anticipated.
AimsDiscovery.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019