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Discovery of a BD1 selective inhibitor of BRD4 and co-targeting its interaction with AMPK-modulating autophagic cell death in breast cancer

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: LIU, Bo (Chengdu, China)
  • Co-author(s): Leilei Fu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center for Biotherapy, Sichuan university, Chengdu, China
    Bo Liu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center for Biotherapy, Sichuan university, Chengdu, China
  • Abstract:

    Backgrounds

    BRD4 is an attractive cancer target, yet its protein-protein interactions (PPIs), which is relevant to therapeutic effects of BRD4 inhibitors, are not well understood. Induction of autophagic cell death (ACD) has been emerging as a new strategy; therefore, targeting ACD for discovering a BRD4 inhibitor will be anticipated.

    Aims

    Discovery

    ..

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Last update 4 October 2019

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