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The β-lactam Clavulanic Acid without Antibacterial Activity mediates Glutamate Transport-sensitive Pain-relief in the Chronic Constriction Injury Rat Model of Neuropathic Pain

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BJERRUM, Ole Jannik (University of Copenhagen, Drug design and pharmacology, Copenhagen, Denmark)
  • Co-author(s): Pernille Kristensen: Drug design and pharmacology, University of Copenhagen, Copenhagen, Denmark
    Georgi Gegelashvili: Instittute of Chemical Biology, Ilia State University, Tbilisi, Georgia
    Gordon Munro: Dept. Neurology, Glostrup Hospital, Glostrup, Denmark
    Anne-Marie Heegaard: Drug design and pharmacology, University of Copenhagen, Copenhagen, Denmark
    Ole Jannik Bjerrum: Drug design and pharmacology, University of Copenhagen, Copenhagen, Denmark
  • Abstract:

    Backgrounds

    Following nerve injury, down-regulation of astroglial glutamate transporters (GluTs) and subsequently extracellular glutamate accumulation is one of the factors contributing to nociceptive signaling. Some β-lactam antibiotics e.g. ceftriaxone can upregulate GluTs and display analgesic effect in  chronic pain models. Following nerve..

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Last update 4 October 2019

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