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Biological responsiveness and pharmacokinetic properties of cellular type hemoglobin based oxygen carrier (Hemoglobin-Vesicles) in hyperlipidemia model mice after massive intravenous injection

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TAGUCHI, Kazuaki (Sojo University, Kumamoto, Japan)
  • Co-author(s): Kazuaki Taguchi: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Keishi Yamasaki: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Hiromi Sakai: Department of Chemistry, Nara Medical University, Nara, Japan
    Toru Maruyama: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Masaki Otagiri: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
  • Abstract:

    Backgrounds

    The hemoglobin-vesicle (HbV), a liposome in which a concentrated human hemoglobin solution is encapsulated, was developed as an artificial oxygen carrier. Although it has been demonstrated that HbV possesses a favorable safety, metabolic, and excretion performance in healthy animals, biological response and metabolic performance under..

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Last update 4 October 2019

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