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Development of a generic physiologically based pharmacokinetic model to predict drug target site concentrations in the CNS

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: YAMAMOTO, Yumi (Leiden University, LACDR, Pharmacology, Leiden, Netherlands)
  • Co-author(s): Yumi Yamamoto: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
    Pyry A. Välitalo: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
    Dirk-Jan van den Berg: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
    Robin Hartman: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
    Yin Cheong Wong: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
    Dymphy R. Huntjens: Quantitative Sciences, Janssen Research & Development, Beerse, Belgium
    Johannes H. Proost: Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, Netherlands
    An Vermeulen: Quantitative Sciences, Janssen Research & Development, Beerse, Belgium
    Walter Krauwinkel: Clinical Pharmacology & Exploratory Development, Astellas Pharma BV, Leiden, Netherlands
    Meindert Danhof: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
    Johan G. C. van Hasselt: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
    Elizabeth C. M. de Lange: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  • Abstract:

    Backgrounds

    Predicting human target site concentrations in the central nervous system (CNS) is challenging because of the presence of the blood-brain barrier and the blood-cerebrospinal fluid barrier. Furthermore, access to human brain samples is restricted because of practical and ethical reasons. A physiologically based pharmacokinetic (PBPK)..

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Last update 4 October 2019

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