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A comparison of performance between parametric and nonparametric estimation for nonlinear mixed-effects models

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: WANG, Shijun (Uppsala University, Department of pharmaceutical bioscience, uppsala, Sweden)
  • Co-author(s): Shijun Wang: Department of pharmaceutical bioscience, Uppsala University, uppsala, Sweden
    Andrew Hooker: Department of pharmaceutical, Uppsala University, Uppsala, Sweden
    Mats Karlsson: Department of pharmaceutical bioscience, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    Nonparametric (NP) methods estimating discrete parameter distributions offer an alternative to parametric methods in pharmacometric analyses.

    Aims

    This study aims to evaluate the performance of the NP estimation method in NONMEM 7 in comparison with the first-order conditional estimation method with interaction (FOCEI)1

    Methods

    The FOCEI

    ..

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Last update 4 October 2019

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