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Novel mechanism of drug-drug interaction between ezetimibe and warfarin via the inhibition of vitamin K absorption

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TAKADA, Tappei (The University of Tokyo Hospital, Department of Pharmacy, Tokyo, Japan)
  • Co-author(s): Tappei Takada: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Yoshihide Yamanashi: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Kentaro Konishi: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Takehito Yamamoto: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Yu Toyoda: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Hideaki Yamamoto: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Yusuke Tanaka: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Toko Komine: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Hiroshi Suzuki: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
  • Abstract:

    Backgrounds

    Vitamin K (VK) is a fat-soluble vitamin involved in the regulation of blood coagulation. Mammals do not synthesize VK and must therefore obtain this vitamin by intestinal absorption. However, the molecular mechanism(s) of VK absorption process were not clear.

    Aims

    Based on the known role of Niemann-Pick C1-like 1 (NPC1L1) protein in the

    ..

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Last update 4 October 2019

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