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Categorical Modelling of a Rat Behavioural Seizure Scoring System to Define Exposure-Response Relationship and Predict the NOEL

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: NORDELL, Pär (AstraZeneca, Drug Metabolism and Disposition, Mölndal, Sweden)
  • Co-author(s): Pär Nordell: Drug Metabolism and Disposition, AstraZeneca, Mölndal, Sweden
    Harish Shankaran: Drug Metabolism and Disposition, AstraZeneca, Boston, United States
    Karen Tse: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
    Glen Hawthorne: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
    William Redfern: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
    Alex Harmer: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
  • Abstract:

    Backgrounds

    In a exploratory rat study with Compound A convulsions were observed at high doses. Accordingly, a study was conducted at 0, 40 and 100 mg/kg to assess exposures in relation to the seizure behavior scored using the modified Racine scale.

    Aims

    PK/PD modelling was undertaken to establish the exposure-response relationship and define a NOEL.

    M

    ..

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Last update 4 October 2019

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