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Human jejunum in the Ussing chamber set-up replicates clinically observed intestinal metabolites

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: AMBERNTSSON, Sara (Astrazeneca, Mölndal, Sweden)
  • Co-author(s): Sara Amberntsson: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, Sweden
    Charlotta Vedin: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, Sweden
    Katarina Breitholtz: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, Sweden
    Katherine Fenner: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, United Kingdom
    Constanze Hilgendorf: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, Sweden
  • Abstract:

    Backgrounds

    Ex vivo studies using fresh intestine in an Ussing chamber set-up are typically used to predict absorption of drug compounds. Metabolism in the gut can be an additional key piece of information when for example loss of absorbed dose is observed in vivo. The Ussing chamber set-up is a comprehensive technique where relevant intestinal..

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Last update 4 October 2019

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