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Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: XIAO, Qiong (Beijing, China)
  • Co-author(s): Qiong Xiao: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Xiaojian Wang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Huaqing Cui: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Hui Wen: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Meiyang Xi: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Xiang Zhang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  • Abstract:

    Backgrounds

    SYL927 and SYL930 are selective S1P1 agonists under preclinical development. However, during their pharmacokinetic studies we detected two metabolites in rat blood that were tentatively identified as monohydroxylated metabolites of SYL927 and SYL930 based on LC–MS/MS data

    Aims

    Identify the monohydroxylated metabolites

    Methods

    We designed

    ..

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Last update 4 October 2019

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