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Development of Hydroxy-Based SphK Inhibitors and Anti-Inflammation in DSS Induced Colitis in Mice

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: XI, Meiyang (Beijing, China)
  • Co-author(s): Meiyang Xi: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Xiaojian Wang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Qiong Xiao: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Hui Wen: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Xiang Zhang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Huaqing Cui: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Dali Yin: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  • Abstract:

    Backgrounds

    Sphingosine kinase (SphK)-catalyzed production of sphingosine-1-phosphate (S1P) regulates cell growth, survival and proliferation as well as inflammatory status in animals. 

    Aims

     to find an anti-inflammatory agent to probably treat inflammatory bowel diseases in human.

    Methods

    SAR  DSS induced mouse models 

    Results

     In recent study we

    ..

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Last update 4 October 2019

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