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3D QSAR-guided identification of oxazole and triazole derivatives as novel, potent and selective S1P1 agonists

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: WANG, Xiaojian (Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Medicinal Chemistry, Beijing, China)
  • Co-author(s): Xiaojian Wang: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Dali Yin: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Qiong Xiao: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Meiyang Xi: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Hui Wen: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Xiang Zhang: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Huaqing Cui: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  • Abstract:

    Backgrounds

    Recently, the Sphingosine 1-phosphate receptor (S1P-R) signaling system has proven to be of biological and medical importance in immune regulation, including blood vessel constriction, heart rate modulation, angiogenesis, etc.

    Aims

    To design novel, potent and selective S1P1 agonists with improved pharmacokinetic profiles based on the

    ..

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Last update 4 October 2019

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