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A new ruthenium complex containing xanthoxylin induces cell cycle arrest in the S phase and causes cell death by apoptosis

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BEZERRA, Daniel (Fundação Oswaldo Cruz, Laboratório de Engenharia Tecidual e Imunofarmacologia, Salvador, Brazil)
  • Co-author(s): Nanashara Carvalho: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
    Sara Neves: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
    Regina Oliveira: Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil
    Milena Soares: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
    Rose Carlos: Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil
    Paulo Nogueira: Department of Chemistry, Federal University of Sergipe, São Cristóvão, Brazil
    Daniel Bezerra: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
  • Abstract:

    Backgrounds

    Ruthenium complexes are of interest as antitumor agents because they have selective anticancer properties and low systemic toxicity. 

    Aims

    The aim of this work was to investigate the underlying mechanisms of the cytotoxicity of cis-[Ru(phen)2(xant)](PF6), a new ruthenium complexe containing xanthoxylin (CXR)

    Methods

    CXR was tested against

    ..

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Last update 4 October 2019

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