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Xylopine, an aporphinic alkaloid, increases ROS levels, induces cell cycle arrest in the G2/M phases and apoptotic cell death in human colon carcinoma cells

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BEZERRA, Daniel (Fundação Oswaldo Cruz, Laboratório de Engenharia Tecidual e Imunofarmacologia, Salvador, Brazil)
  • Co-author(s): Luciano Santos: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
    Valdenizia Silva: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
    Leociley Menezes: Department of Chemistry, Federal University of Sergipe, São Cristóvão, Brazil
    Milena Soares: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
    Emmanoel Costa: Department of Chemistry, Federal University of Amazonas, Manaus, Brazil
    Daniel Bezerra: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
  • Abstract:

    Backgrounds

    Xylopine is an aporphinic alkaloid found mainly in plants of the Annonaceae family. It showed promising cytotoxic activity in previous studies in our laboratory.

    Aims

    The aim of this work was to investigate the underlying mechanisms of the cytotoxicity of xylopine. 

    Methods

    Xylopine was isolated from the stem of Xylopia leavigata and tested

    ..

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Last update 4 October 2019

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