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Drug supersaturation versus precipitation: experimental models of gastrointestinal absorption of fenofibrate from lipid-based delivery systems

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: POUTON, Colin (Monash University, Monash Institute of Phamaceutical Sciences, Parkville, Australia)
  • Co-author(s): Matt Crum: Monash Institute of Phamaceutical Sciences, Monash University, Parkville, Australia
    Natalie Trevaskis: Monash Institute of Phamaceutical Sciences, Monash University, Parkville, Australia
    Colin Pouton: Monash Institute of Phamaceutical Sciences, Monash University, Parkville, Australia
    Chris Porter: Monash Institute of Phamaceutical Sciences, Monash University, Parkville, Australia
  • Abstract:

    Backgrounds

    Lipid delivery systems are often a good option for oral delivery of poorly water soluble drugs. Paradoxically, in vitro tests often predict that digestion of the lipid formulation will result in precipitation of drug in the gut lumen.  The balance between drug supersaturation and precipitation is likely to determine the

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Last update 4 October 2019

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