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Induction of UDP-glucuronosyltransferase 1A1 during the perinatal period can reduce blood thyroxine levels, causing neurodevelopmental toxicity

  • At: 2016 FIP Congress in Buenos Aires (Argentina)
  • Type: Presentation
  • By: FUJIWARA, Ryoichi (Kitasato University, School of Pharmacy, Tokyo, Japan)
  • Co-author(s): Ryoichi Fujiwara:School of Pharmacy,Kitasato University,Tokyo,Japan|Yuki Kutsuno:School of Pharmacy,Kitasato University,Tokyo,Japan|Tomoo Itoh:School of Pharmacy,Kitasato University,Tokyo,Japan
  • Abstract:

    Clinical data indicate that anticonvulsants such as phenytoin increase a risk of developing neurodevelopmental disorders; however, the underlying mechanism has not been elucidated. Thyroxine (T4) plays crucial roles in the development of the central nervous system. It has been reported that phenytoin can induce UDP-glucuronosyltransferase (UGT)


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Last update 4 October 2019

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