Induction of UDP-glucuronosyltransferase 1A1 during the perinatal period can reduce blood thyroxine levels, causing neurodevelopmental toxicity
- At: 2016 FIP Congress in Buenos Aires (Argentina)
- Type: Presentation
- By: FUJIWARA, Ryoichi (Kitasato University, School of Pharmacy, Tokyo, Japan)
- Co-author(s): Ryoichi Fujiwara:School of Pharmacy,Kitasato University,Tokyo,Japan|Yuki Kutsuno:School of Pharmacy,Kitasato University,Tokyo,Japan|Tomoo Itoh:School of Pharmacy,Kitasato University,Tokyo,Japan
Clinical data indicate that anticonvulsants such as phenytoin increase a risk of developing neurodevelopmental disorders; however, the underlying mechanism has not been elucidated. Thyroxine (T4) plays crucial roles in the development of the central nervous system. It has been reported that phenytoin can induce UDP-glucuronosyltransferase (UGT).. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.