Simultaneous rapid separation and determination of fosphenytoin, phenytoin and their main metabolite 4'-hydroxyphenytoin in human plasma using isocratic reversed-phase HPLC
- At: 2007 FIP Congress in Beijing (China)
- Type: Poster
- By: MA, Chunlai (Huashan Hospital, Fudan University, Shanghai, China)
- Co-author(s): Jiao, Zheng (Huashan Hospital, Fudan University, SHANGHAI, China)
Ying, Yinqing (Shanghai Health School, SHANGHAI, China)
Shi, Xiaojin (Huashan Hospital, Fudan University, SHANGHAI, China)
OBJECTIVE To develop a simple reversed-phase high-performance liquid chromatography (HPLC) method for the simultaneous determination of the antiepileptic drugs (AEDs) phenytoin (PHT), its prodrug fosphenytoin (FOS), and its metabolite 4â€²-hydroxyphenytoin (4â€²-HPPH) in human plasma. METHODS Plasma sample (100 Î¼L) pre-treatment involved.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.