Simultaneous rapid separation and determination of fosphenytoin, phenytoin and their main metabolite 4'-hydroxyphenytoin in human plasma using isocratic reversed-phase HPLC

• At: 2007 FIP Congress in Beijing (China)
• Type: Poster
• By: MA, Chunlai (Huashan Hospital, Fudan University, Shanghai, China)
• Co-author(s): Jiao, Zheng (Huashan Hospital, Fudan University, SHANGHAI, China)
  Ying, Yinqing (Shanghai Health School, SHANGHAI, China)
  Shi, Xiaojin (Huashan Hospital, Fudan University, SHANGHAI, China)
  
• Abstract:

  OBJECTIVE To develop a simple reversed-phase high-performance liquid chromatography (HPLC) method for the simultaneous determination of the antiepileptic drugs (AEDs) phenytoin (PHT), its prodrug fosphenytoin (FOS), and its metabolite 4′-hydroxyphenytoin (4′-HPPH) in human plasma. METHODS Plasma sample (100 μL) pre-treatment involved

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