Lovastatin protection from intestinal metabolism by oral lipid particles and bioavailability study
- At: 2007 FIP Congress in Beijing (China)
- Type: Poster
- By: GAN, Yong (Shanghai Institute of Materia Medica, Shanghai, China)
- Co-author(s): Ge, Zhen (Shanghai Institute of Materia Medica, SHANGHAI, China)
Zhang, Xinxin (Shenyang Pharmaceutical University, SHENYANG, China)
Zhu, Chunliu (Shanghai Institute of Materia Medica, SHANGHAI, China)
OBJECTIVE To prepare lovastatin-loaded oral lipid particles drug delivery system and investigate protective effects from intestinal CYP3A4 metabolism and the influence of oral bioavailability. METHOD Phosal 53 MCTÂ[RSYMBOL] , Tween 80 and Starch Sodium Octenyl Succinatd were employed as oil phase, emulsifying agent and matrix material,.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.