PREDICTION OF DRUG CLEARANCE IN ELDERLY PATIENTS USING THE SIMCYP GERIATRICS MODEL.
- At: 2015 FIP Congress in Düsseldorf (Germany)
- Type: Presentation
- By: CHETTY, Manoranjenni (Simcyp, Sheffield, United Kingdom)
- Co-author(s): Manoranjenni Chetty
Physiological changes that may impact drug clearance in the elderly are frequently reported, although they may be challenging to quantify. The recently developed Simcyp population-based PBPK geriatrics model accounts for age-related physiological changes such as liver volume, kidney weight, renal function and demographic distributions.
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