DISCOVERY AND BIOLOGICAL EVALUATION OF NOVEL 1,2,4-TRIAZINE DERIVATIVES AS C-MET KINASE INHIBITORS
- At: 2015 FIP Congress in Düsseldorf (Germany)
- Type: Poster
- By: LABOUTA, Ibrahim (Alexandria University, Faculty of Pharmacy, Pharmaceutical Chemistry, Alexandria, Canada)
- Co-author(s): Ibrahim Labouta
Tyrosine kinase c-Met is the high-affinity receptor for hepatocyte growth factor (HGF) and HGF/c-Met axis is often dysregulated in tumors. Recent strategies have been employed to interrupt the c-Met signaling pathway. Significant progress was made to develop small-molecule c-Met inhibitors, some of which reached clinical trials. Among heterocycles.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.