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DISCOVERY AND BIOLOGICAL EVALUATION OF NOVEL 1,2,4-TRIAZINE DERIVATIVES AS C-MET KINASE INHIBITORS

  • At: 2015 FIP Congress in Düsseldorf (Germany)
  • Type: Poster
  • By: LABOUTA, Ibrahim (Alexandria University, Faculty of Pharmacy, Pharmaceutical Chemistry, Alexandria, Canada)
  • Co-author(s): Ibrahim Labouta
  • Abstract:

    Tyrosine kinase c-Met is the high-affinity receptor for hepatocyte growth factor (HGF) and HGF/c-Met axis is often dysregulated in tumors. Recent strategies have been employed to interrupt the c-Met signaling pathway. Significant progress was made to develop small-molecule c-Met inhibitors, some of which reached clinical trials. Among heterocycles

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Last update 4 October 2019

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