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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SPIROISOXAZOLIN DERIVATIVES AS SELECTIVE COX-2 INHIBITORS

  • At: 2015 FIP Congress in Düsseldorf (Germany)
  • Type: Poster
  • By: ABOLHASANI, Hoda (School of Medicine, Qom University of Medical Sciences, Qom, Iran, Departement of Pharmacology, Qom, Iran)
  • Co-author(s): Hoda Abolhasani
  • Abstract:

    Chronic inflammation may be a causative factor in a variety of cancers. Selective COX-2 inhibitors are used as anti-inflammatory agents and COX-2 over expression has been demonstrated in several cancers.

     

    New spiroisoxazoline derivatives were designed and synthesized for evaluation as selective COX-2 inhibitors by Cayman kit. Docking studies were

    ..

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Last update 4 October 2019

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