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Pharmacokinetics and cytotoxicity of vorinostat-loaded solid lipid nanoparticles: preparation and characterization

  • At: 2014 FIP Congress in Bangkok (Thailand)
  • Type: Poster
  • By: YONG, Chul Soon (Yeungnam University, College of Pharmacy, Gyeongsangbuk-do, South-Korea)
  • Co-author(s): Tran, Tuan Hiep (Yeungnam University, Gyeongsangbuk-do, South-Korea)
    Choi, Ju Yeon (Yeungnam University, Gyeongsangbuk-do, South-Korea)
    Jeong, Jee-Heon (Yeungnam University, Gyeongsangbuk-do, South-Korea)
    Kim, Jong Oh (Yeungnam University, Gyeongsangbuk-do, South-Korea)
    Tak, Jin Wook (Yeungnam University, Gyeongsangbuk-do, South-Korea)
    Ramasamy, Thiruganesh (Yeungnam University, Gyeongsangbuk-do, South-Korea)
    Kim, Dong Wuk (2College of Pharmacy, Hanyang University, Ansan, South-Korea)
  • Abstract:

    Background and Aims: The aim of study is to enhance bioavailability and effects on cancer cells of vorinostat (VRS), using solid lipid nanoparticles (SLNs).
    Methods: VRS-loaded SLNs (V-SLNs) were prepared by hot homogenization using an emulsification-sonication technique, and the formulation parameters were optimized. The SLN were characterized..

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Last update 4 October 2019

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