Pharmacokinetics and cytotoxicity of vorinostat-loaded solid lipid nanoparticles: preparation and characterization

• In: Posters: Industrial Pharmacy Section
• At: Bangkok (Thailand) (2014)
• Type: Poster
• Poster code: POS-IPS011
• By: YONG, Chul Soon (Yeungnam University, College of Pharmacy, Gyeongsangbuk-do, South-Korea)
• Co-author(s): Tran, Tuan Hiep (Yeungnam University, Gyeongsangbuk-do, South-Korea)
  Choi, Ju Yeon (Yeungnam University, Gyeongsangbuk-do, South-Korea)
  Jeong, Jee-Heon (Yeungnam University, Gyeongsangbuk-do, South-Korea)
  Kim, Jong Oh (Yeungnam University, Gyeongsangbuk-do, South-Korea)
  Tak, Jin Wook (Yeungnam University, Gyeongsangbuk-do, South-Korea)
  Ramasamy, Thiruganesh (Yeungnam University, Gyeongsangbuk-do, South-Korea)
  Kim, Dong Wuk (2College of Pharmacy, Hanyang University, Ansan, South-Korea)
  
• Abstract:

  Background and Aims: The aim of study is to enhance bioavailability and effects on cancer cells of vorinostat (VRS), using solid lipid nanoparticles (SLNs).
  Methods: VRS-loaded SLNs (V-SLNs) were prepared by hot homogenization using an emulsification-sonication technique, and the formulation parameters were optimized. The SLN were characterized..

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