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Improving the bioavailability of ramipril by mucoadhesive buccal patches

  • At: 2014 FIP Congress in Bangkok (Thailand)
  • Type: Poster
  • By: JAIN, Prateek (Manipal College of Pharmaceutical Sciences, Manipal University, Manipal College of Pharmaceutical Sciences, Manipal, India)
  • Co-author(s): Edavi, Ved G. (Indira Institute of Pharmacy, Sadavali, ratnagiri, maharashtra, India)
    Khade, Amol B. (Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India)
    Mane, Prashant P. (Indira Institute of Pharmacy, Sadavali, ratnagiri, maharashtra, India)
    Udupa, Nayanabhirama (Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India)
  • Abstract:

    Background
    The buccal region offers an attractive route of drug administration for systemic drug delivery. Ramipril, an ACE inhibitor, used to treat high blood pressure and conjestive heart failure, has an oral bioavailablity of approximately 28% due to its extensive first pass metabolism. Also it has a half-life of 2-4 hr that leads to frequent..

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Last update 4 October 2019

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