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Enhanced bioavailability of poorly water-soluble clotrimazole by inclusion with ?-cyclodextrin

  • At: 2006 FIP Congress in Salvadore (Brazil)
  • Type: Poster
  • By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, South-Korea)
  • Co-author(s): Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kwak, Mi-Kyoung (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Yoo, Bong-Kyu (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kim, Jung-Ae (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Lyoo, Won Seok (School of Textiles, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Newa, Madhuri (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Bhandari, Krishna Hari (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Balakrishnan, Prabagar (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Xuan, Jing-Ji (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Li, Dong-Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Piao, Ming-Guan (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  • Abstract:

    Purpose: The aim of the study was to investigate the enhanced solubility, dissolution and bioavailability of clotrimazole by inclusion complex with ß-cyclodextrin. Method: In different molar ratios clotrimazole and ß- CD were dissolved in ethanol and water, respectively, and mixed together to obtain clear solution. The resulting solutions were..

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Last update 4 October 2019

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