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Design, synthesis and in vitro characterization of peptide based gene delivery systems

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: CHRISTIE, Michelle (The University of Queensland, School of Chemistry and Molecular Biosciences, St lucia, Australia)
  • Co-author(s): Moyle, Peter (The University of Queensland, St lucia, Australia)
    Rosli, Nurlina (The University of Queensland, St lucia, Australia)
    Khairul, Kamaruzaman (The University of Queensland, St lucia, Australia)
    Wan, Yu (The University of Queensland, St lucia, Australia)
    Toth, Istvan (The University of Queensland, St lucia, Australia)
  • Abstract:

    Background - The delivery of exogenous oligonucleotide therapeutics to their target site presents significant challenges. Therapeutic DNA/RNA has to overcome many physiological barriers to reach the cytoplasm (RNA) or the nucleus (full-length genes). These barriers include movement across the plasma membrane, endosomal release and in the case of..

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Last update 4 October 2019

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