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Polymyxins accumulate in rat kidney tubular cells and induce apoptosis

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: AZAD, Mohammad Abul Kalam (Monash Institute of Pharmaceutical Sciences, Pharmaceutics, Melbourne, Australia)
  • Co-author(s): Robers, Kade D. (Monash Institute of Pharmaceutical Sciences, Melbourne, Australia)
    James, Simon (X-ray fluorescence microscopy Beamline Team, Melbourne, Australia)
    Howard, Daryl L. (X-ray fluorescence microscopy Beamline Team, Melbourne, Australia)
    Nation, Roger L. (Monash Institute of Pharmaceutical Sciences, Melbourne, Australia)
    Rogers, Kelly (Centre for Dynamic Imaging, The Walter & Eliza Hall Institute, Melbourne, Australia)
    de Jonge, Martin D. (X-ray fluorescence microscopy Beamline Team, Melbourne, Australia)
    Yu, Heidi H. (Monash Institute of Pharmaceutical Sciences, Melbourne, Australia)
    Thompson, Philip E. (Monash Institute of Pharmaceutical Sciences, Melbourne, Australia)
    Fu, Jing (Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, Australia)
    Velkov, Tony (Monash Institute of Pharmaceutical Sciences, Melbourne, Australia)
    Li, Jian (Monash Institute of Pharmaceutical Sciences, Melbourne, Australia)
  • Abstract:

    Background: Polymyxins (PM), the last-line therapy for Gram-negative 'superbugs', can cause nephrotoxicity in ~60% of patients. PM-induced nephrotoxicity is the dose-limiting factor and is associated with apoptosis of tubular cells.
    Aims: This study aimed to quantitatively map the localisation of PM in NRK-52E cells and examine the roles of..

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Last update 4 October 2019

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