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DESIGN OF PROTEIN KINASE INHIBITORS USING STAUROSPORINE AS A LEAD
- At: AbuDhabi (United Arab Emirates) (2019)
- Type: Poster
- Poster code: POS-DDD-009
- By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
- Co-author(s): Elena Mallia: Pharmacy, University of Malta, Msida, Malta
Claire Shoemake: Pharmacy, University of Malta, Msida, Malta - Abstract:
Background
The protein kinase C (PKc) family is a target in cancer management. PKc inhibitors have an important role in cancer chemotherapy1. Staurosporine, isolated from Streptomyces staurosporeus is an ATP-competitive kinase inhibitor capable of inducing cellular apoptosis2.
Methods
PDB crystallographic deposition 1STC describing the bound.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 23 September 2026